LLeaders Manchester City are without Kyle Walker and John Stones as they host Newcastle hoping to move three points clear of Liverpool at the top of the table.
None of the defenders were able to prove their fitness, meaning City started with a four-man defense of Joao Cancelo, Ruben Dias, Aymeric Laporte and Oleksandr Zinchenko, the same one that ended against Real Madrid in midweek.
Other changes made by manager Pep Guardiola include Ilkay Gundogan, Jack Grealish and Raheem Sterling replacing Bernardo Silva, Phil Foden and Riyad Mahrez.
Newcastle are without Jonjo Shelvey and Joe Willock, but Chris Wood and Jamaal Lascelles are back. Kieran Trippier, Callum Wilson and Fabian Schar are on the bench after recent injuries.
city man: Ederson, Joao Cancelo, Dias, Laporte, Zinchenko, De Bruyne, Rodri, Gundogan, Sterling, Gabriel Jesus, Grealish.
Substitutes: Ake, Steffen, Bernardo Silva, Fernandinho, Mahrez, Foden, Egan-Riley, Mbete-Tabu, Palmer.
New Castle: Dubravka, Krafth, Lascelles, Burn, Targett, Bruno Guimaraes, Longstaff, Joelinton, Almiron, Wood, Saint-Maximin.
Substitutes: Dummett, Schar, Wilson, Ritchie, Trippier, Manquillo, Murphy, Darlow, Gayle.
Referee: Stuart Attwell (Warwickshire)